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KMID : 0370219970410050595
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Yakhak Hoeji
1997 Volume.41 No. 5 p.595 ~ p.601
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Synthesis Conditions of Thiamine Mononitrate and Pharmaceutical Stability of Thiamine Monosalts
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박홍구/Park HK
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Abstract
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The optimal synthesis condition based on the yield of thiamine mononitrate has been attained according to Box-wilson experimental design. The optimal condition was as follows : Molar concentration ratio of SB1.HCL=0.6839, quantity of NH4NO3=50.09g, agitation velocity=51.6rpm, reaction temperature=22.8oC. The stabilities of three kinds of thiamine monosalts(thiamine monoiodide, -monobromide, -monorhodanate) were investigated in sterile solution, compressed tablet and multivitamin capsule, respectively. Assay data are given to show that thiamine monosalts are not significantly higher than that of thiamine mononitrate in sterile solutions and the addition of an acidic stabilizer is unnecessary. The solutions were clear and free of precipitate and didn’t discolored after storage at room temperature and 40oC for 6 months. The tablets and capsules were assayed initially and at predetermined intervals during storage at room temperature and 40oC for 6 months. Thiamine monorhodanate was found to be more stable than other thiamine monosalts in these compressed tablets containing other vitamin of the B complex and the data indicate that thiamine monosalts was similar to that of thiamine mononitrate in the multivitamine capsules.
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